JNTU
JNTU B.Pharmacy IV EXPERIMENTAL PHARMACOLOGY Previous Question Paper (July - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Name the different routes of drug administration to animals.
Answer
Common routes include oral (gavage), intravenous, intramuscular, intraperitoneal, subcutaneous, intradermal, and inhalation.
Name the techniques for the collection of blood from the animals.
Answer
Techniques include tail vein puncture, retro-orbital plexus puncture, cardiac puncture, saphenous vein puncture, and jugular vein catheterization.
Write the name different methods for grouping of animals.
Answer
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Write about parameters for the selection of preclinical screening models.
Answer
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Name two parasympathomimetics and parasympatholytics.
Answer
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Write the principle and uses of rotarod apparatus.
Answer
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Write name of In-vitro tests to check anti-cancer activity of compounds.
Answer
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Write the principle and uses of lipschitz test.
Answer
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Differentiate between null and alternate hypothesis with suitable examples.
Answer
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Write the methods for determination of central tendency and dispersion of data.
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Part B
Write in detail about the description and applications of different species and strains of laboratory animals.
Answer
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Write detail of collection of blood and storing samples. Differentiate between Anesthesia, Analgesia and Euthanasia.
Answer
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Describe the various steps involved in the conversion of animal dose into Maximum Recommended Safe Dose (MRSD) in human and how do you select dose.
Answer
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Write the average weight and feed intake per day, uses of rat, mice, guinea pig and rabbits. Also, write in detail about grouping of animals for any pharmacological experiment.
Answer
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Write in detail about animal models used for screening of sympatholytics.
Answer
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Write in detail about animal models used for screening of parasympatholytics.
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Explain the breast cancer In-vitro and In-vivo models along with their limitations and advantages.
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Explain about In-vitro and In-vivo models for hepatic cancer along with their limitations and advantages.
Answer
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Differentiate between paired and unpaired student t test along with suitable examples.
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Write in detail about various methods of graphical representation of data.
Answer
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