JNTU
JNTU B.Pharmacy IV EXPERIMENTAL PHARMACOLOGY Previous Question Paper (June - 2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Name the Techniques for Euthanasia.
Answer
Techniques for euthanasia include physical methods (e.g., cervical dislocation, decapitation) and chemical methods (e.g., inhalation of CO2, overdose of barbiturates or anesthetic gases).
Write a short note on Routes of drug Administration.
Answer
Routes of drug administration are categorized into enteral (oral, sublingual, rectal) and parenteral (intravenous, intramuscular, subcutaneous, intraperitoneal). The choice depends on the drug's physicochemical properties, required onset of action, and the target site in the experimental animal.
Explain the preparation of drug solution in regard with various solvents used.
Answer
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Define Blinding and Randomisation.
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Write any screening model for Sympathomimetics.
Answer
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Define Skeletal muscle relaxants and write any one screening model.
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Write the mechanisms of action of anticoagulants.
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Write any Preclinical screening model for Anticancer activities.
Answer
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Define Parametric and Nonparametric tests.
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Define Research and name the types of Research.
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Part B
Write a brief note on Maintenance of Laboratory Animals and use of Transgenic animals in Preclinical Screening methods.
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Write a brief note on Mutant Animals and Techniques for collection of blood.
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Discuss the importance of Sham negative and positive control groups in preclinical studies and role of these control groups in assessing experimental outcomes.
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Explain in detail about Calculation and Conversions in Dose selection.
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Describe Various Screening models for Sympatholytic drugs and Explain any one model in detail.
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Describe two Screening methods for Skeletal muscle relaxant drugs.
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Explain any three pre clinical screening methods for Anti cancer drugs.
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Explain any two pre clinical screening methods for Diuretics.
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Compare the different types of study designs like Observational studies, Experimental studies, Clinical trails and write the strengths and limitations of each type of study design.
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The three samples below have been obtained from normal populations with equal variances. Test the hypothesis that the sample means are equal.
Data –A: 8, 10, 7, 14, 11, 16
Data -B: 8, 6, 1, 8, 8, 13
Data -C: 17, 10, 12, 12, 15, 12
Answer
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