Jawaharlal Nehru Technological University Hyderabad
Jawaharlal Nehru Technological University Hyderabad B.Pharmacy I Year PHARMACEUTICAL ANALYSIS Previous Question Paper (January-2018 - R17)
Note: This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b, c as sub questions.
Part A
Write and explain the Henderson equation.
Answer
The Henderson-Hasselbalch equation is: pH = pKa + log([Salt]/[Acid]). It relates the pH of a buffer solution to the pKa of the weak acid and the ratio of the concentrations of the conjugate base (salt) and the weak acid.
What is the solubility product of silver chloride if its solubility at 25°C is 1.86×10-4?
Answer
For silver chloride (AgCl), the dissociation is AgCl ⇌ Ag+ + Cl-. Given solubility (s) = 1.86 × 10^-4 M. The solubility product (Ksp) is calculated as: Ksp = [Ag+][Cl-] = s × s = s^2. Ksp = (1.86 × 10^-4)^2 = 3.46 × 10^-8.
Write the importance of de masking in complexometry.
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Explain the preparation of 500 ml of 0.1M potassium hydrogen phthalate.
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Name indicator and reference electrode for acid base and redox titrations.
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Explain the rejuvenation of glass electrode.
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What are the differences between “Isocratic” and “Gradient” elution?
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Explain the terms HETP, retention time in brief.
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List the types of nebulizers in flame photometry.
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How 750 ml of 4000 NTU formazine solution is prepared? What purpose it is used?
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Part B
Explain the steps in the calibration of a pH meter.
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Explain Lewis concept of acids and bases with two examples.
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Classify the redox indicators with two examples for each class. Explain the mechanism of action of any one indicator from each class.
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Define the term pH of a solution. What is pH scale? Calculate the pH of 10-3 M solution of potassium hydroxide.
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Explain the general methods of edetate titrations.
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Classify the solvents and indicators used in Non-Aqueous titrations with examples.
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Explain the precipitation in gravimetry from homogeneous solution with relevant examples.
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Explain the precautions to be observed in the preparation and during usage of acetous perchloric acid titrant.
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Explain the construction and care of glass electrode.
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Explain the conductometric titration curve for the mixture of strong acid and weak acid vs strong base and weak base.
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List the advantages and disadvantages of potentiometric titration over titrations using indicators.
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Write and explain Ilkovic equation. Write its use.
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How the development is carried out in Column chromatography, TLC and Paper chromatography?
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Explain the special methods for the preparation of TLC plates.
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Explain the quantitative techniques in TLC.
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Write the merits and demerits of Paper chromatography over TLC.
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Explain the standard addition method in flame photometry.
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Explain the factors affecting specific rotation of a drug substance.
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Explain briefly the physical and chemical methods for the determination of moisture content in a drug substance.
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Write the working of Lundergarph Burner.
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