JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy I Year PHARMACEUTICAL INORGANIC CHEMISTRY-I Previous Question Paper (January-2018 - R17)
Note: This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b, c as sub questions.
Part A
Give the principle behind the limit test for chloride.
Answer
The limit test for chloride is based on the chemical reaction between chloride ions and silver nitrate in the presence of dilute nitric acid. This reaction results in the formation of silver chloride, which appears as an opalescence or turbidity in the solution. The intensity of this turbidity is compared against a standard chloride solution to determine if the sample meets the purity limit.
Explain different types of impurities involved in pharmaceutical substances.
Answer
Impurities in pharmaceutical substances are classified into three main types:
- Organic and Inorganic Impurities: These include starting materials, intermediates, reagents, catalysts, and heavy metals.
- Residual Solvents: These are volatile organic chemicals used or produced during the manufacturing process.
- Related Substances: These are degradation products or impurities structurally related to the active pharmaceutical ingredient.
What are buffers and explain their buffering capacity.
Answer
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Write various methods of adjusting tonicity.
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What are cathartics? Give two examples.
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Give the preparation, assay principle and uses of chlorinated lime.
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What are expectorants? Give two examples.
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Write the preparation and uses of ferrous sulphate.
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What are radioisotopes and explain their half life.
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Write a note on sodium iodide.
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Part B
Write the principle involved in the limit test of arsenic and iron.
Answer
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Explain the modified limit test for chloride and sulphate.
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Give the general method of preparation, assay and uses of sodium chloride.
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Explain the role of various physiological ions in the body. Write a note on ORS.
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What are acidifiers? Give the general method of preparation, assay and uses of ammonium chloride.
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Write the importance of iodine and give monograph of Sodium Iodide.
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Define emetics. Write a note on copper sulphate.
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Explain antidote and astringents with examples. Write the method of preparation, assay and uses of copper sulphate.
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Explain radioactivity, ways to measure radioactivity and properties of various radioactive radiations.
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Discuss briefly about storage conditions required and precautions to be taken while using radioactive materials. Write the pharmaceutical applications of radioactive substances.
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