Jawaharlal Nehru Technological University Hyderabad
Jawaharlal Nehru Technological University Hyderabad B.Pharmacy I Year PHARMACEUTICAL INORGANIC CHEMISTRY-I Previous Question Paper (September - 2024 - R17)
Note: i) The Question paper consists of Part A and Part B.
ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions.
iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and has a, and b as sub-questions.
Part A
Define the terms Pharmacopoeia and Monographs of pharmacopoeia.
Answer
A Pharmacopoeia is an official publication issued by a government authority that contains a list of medicinal drugs, chemicals, and pharmaceutical preparations along with their standards of purity, quality, and methods of testing. A Monograph is a detailed document within the pharmacopoeia that provides specific information for a single substance, including its chemical structure, identification tests, purity requirements, assay methods, and storage conditions.
Write the modifications of limit test for sulphates.
Answer
The limit test for sulphates is modified by adding a small amount of alcohol to the reaction mixture to prevent supersaturation and ensure the uniform precipitation of barium sulphate. Additionally, a specific quantity of barium chloride reagent is added to the test solution in the presence of dilute hydrochloric acid to ensure that the precipitation is strictly due to the presence of sulphate ions, thereby improving the sensitivity and clarity of the turbidity comparison.
Explain the role of fluoride in tooth decay.
Answer
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Write the applications of buffers in pharmaceuticals systems.
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Give the therapeutic uses of Acidifiers and Antacids.
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Name two inorganic antimicrobials and mention their chemical properties.
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What are the medicinal uses of (i) Expectorants and (ii) Astringents?
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Describe the assay procedure of ferrous sulphate showing the chemical reactions involved.
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Define the term Radiopharmaceuticals and name a radioisotope used for diagnostic purpose.
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Describe the properties of α, β, and γ radiations.
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Part B
Describe briefly the sources of impurities in pharmaceutical substances. Explain the principle involved and describe the procedure of limit test for Arsenic.
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Write an account on the history of the Indian Pharmacopoeia and describe the salient features of the current edition of the Indian Pharmacopoeia.
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Derive and explain the buffer equation for acidic buffer taking an example. What is meant by the term “Buffered isotonic solutions”?
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What is “Physiological acid base balance” and what is its significance? Explain how the body maintain the physiological pH.
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What is the role of gastric acidifiers and how do they act? Describe the properties and assay procedure of Dilute Hydrochloric Acid, IP.
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What are cathartics and how do they act? Write a brief note on bentonite covering its physical-chemical properties and uses.
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What is the therapeutic utility of emetics? Describe the preparation, properties, and assay procedure of copper sulphate.
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What are the different ways that various antidotes act with an ingested toxic substance? Describe the chemical properties and utility of sodium thiosulphate as antidote.
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Define “Half Life” of radionuclides giving examples. Explain the principle and method of measuring radioactivity by anyone technique.
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Discuss the storage requirements and precautions necessary for handling radioisotopes. Describe the utility of any one radiopharmaceutical preparation indicating the radionuclide present.
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