JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B. Pharmacy II PHARMACEUTICAL ORGANIC CHEMISTRY-II Previous Question Paper (March - 2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Write the structure and use of DDT?
Answer
DDT (Dichlorodiphenyltrichloroethane) consists of two chlorophenyl groups attached to a central carbon atom, which is also bonded to a trichloromethyl group. Its structure is 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane.
It is primarily used as a potent insecticide to control diseases like malaria and typhus by targeting mosquitoes and lice, though its use is now heavily restricted or banned in many countries due to environmental persistence and toxicity.
Define electrophiles? Give two examples for electrophiles.
Answer
Electrophiles are electron-deficient chemical species that possess an empty orbital or a partial positive charge, allowing them to accept an electron pair from a nucleophile to form a new chemical bond. They are often referred to as Lewis acids.
Examples of electrophiles include:
- Nitronium ion (NO₂⁺): A positively charged species that acts as a strong electrophile in aromatic substitution reactions.
- Boron trifluoride (BF₃): A neutral molecule with an incomplete octet on the boron atom, allowing it to accept a lone pair of electrons.
Give the structure and uses of m-cresol and β-napthol
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Give qualitative test of phenol.
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What are fatty acids? Give an example for saturated fatty Acids.
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What do mean by Reichert Meissl (RM) value? Give its significance.
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Give the nitration reaction of naphthalene.
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Give the nitration reaction of anthracene.
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Give addition reactions of cyclopropanes.
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Write wurtz’s synthesis of cycloalkane.
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Part B
What is Electrophilic aromatic substitution reaction? Discuss the mechanism of Nitration of benzene.
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Explain the mechanism of halogenation of benzene.
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Discuss the orientation effect of Hydroxyl and amino group in benzene.
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Define activating and deactivating groups with examples. Discuss the Mechanism of sulphonation of benzene.
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What are phenols? Give any three methods of preparation of phenol.
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Write a note on acidity of phenol.
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Write any three methods of preparation of aromatic amines.
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Give synthetic uses of aryl diazonium salts.
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Enlist analytical constants of oils and fats. Discuss in detail about acid value.
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Define Ester value. Give the principle involved in the determination of Estervalue.
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Explain chemical reaction of fatty acid.
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Write a note on the types of rancidity and the methods for prevention of rancidity.
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Define and classify poly nuclear hydrocarbons. Give four chemical reactions of Phenanthrene.
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Give any three synthesis of anthracene.
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Write the structure and medicinal uses of naphthalene, anthracene, Diphenylmethane and phenanthrene.
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Give four chemical reactions of naphthalene.
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Mention the general two method of preparation and two Chemical reactions of cycloalkanes.
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Explain the stability of cycloalkanes on the basis of Bayer strain theory.
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Define anglestrain. Discuss why higher cycloalkanes are more stable than lower members.
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Give any four methods of synthesis of cyclobutane.
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