JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy II Year PHYSICAL PHARMACEUTICS-I Previous Question Paper (December-2019 - R17)
Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b as sub questions.
PART - A
Define dielectric constant and optical rotation.
Answer
Dielectric constant is the ratio of the permittivity of a substance to the permittivity of free space, representing a material's ability to store electrical energy in an electric field. Optical rotation is the angle through which the plane of polarization of plane-polarized light is rotated when passing through an optically active substance.
What are eutectic mixtures? Summarize their significance in pharmaceutical industry.
Answer
Eutectic mixtures are solid mixtures of two or more substances that melt at a temperature lower than the melting points of the individual components. In pharmacy, they are significant for preparing topical powders, liquid mixtures, and solid dispersions to enhance the dissolution rate and bioavailability of poorly water-soluble drugs.
State and explain Raoult’s law.
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Discuss the factors influencing the solubility of gases in liquids.
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Define angle of repose and carr’s consolidation index.
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Write the applications of micrometrics in pharmacy.
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Classify complexes.
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Write the pharmaceutical applications of complexation.
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Define buffer and buffer capacity.
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Discuss the reasons for adjusting pH of a dosage form.
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PART - B
Explain with a neat labeled diagram construction and working method of refractometer.
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Describe the different types of glassy states of materials.
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Discuss any two methods used to determine the dissociation constant of a substance.
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Write the significance of dissociation constant.
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State and explain distribution law and write its applications.
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Discuss solute-solvent interactions with respect solubility phenomena.
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Explain principle, working and applications of fractional distillation process.
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Write the conditions and limitations of Raoult’s law.
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Describe the Andreasen pipette method of analyzing the particle size of powder.
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Explain the principle and working of air permeability method used to determine specific surface of particles.
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Explain the working principle and advantages coulter-counter with the help of neat diagram.
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Mention the applications of sedimentation method of particle size analysis.
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Describe stoichiometric ratio in the analysis of complexation. Describe one method of determining the same.
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Describe any one method used to determine the drug-protein binding.
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Discuss the metal complexes with suitable examples.
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Explain the factors affecting protein binding of drugs.
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Derive Handrson-Hasselbalch equation for the buffer solution pH of weak base and its salts.
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Discuss the role of buffers in pharmaceutical and biological systems.
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Write a note on pharmaceutical buffers.
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Describe the methods used for the determination of tonicity of a system.
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