JNTU
JNTU B.Pharmacy II MEDICINAL CHEMISTRY-I Previous Question Paper (December - 2019 - R17)
This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b, c as sub questions.
Part A
What is meant by ionization? Give one example.
Answer
Ionization is the process by which an atom or a molecule acquires a negative or positive charge by gaining or losing electrons, often in the presence of a solvent. An example is the dissociation of hydrochloric acid (HCl) in water to form H+ and Cl- ions.
What are optical isomers? Give few examples.
Answer
Optical isomers are stereoisomers that are non-superimposable mirror images of each other, known as enantiomers. They rotate the plane of polarized light in opposite directions. Examples include L-Dopa and D-glucose.
What are adrenergic neurotransmitors?
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What is Epinephrine? Give the structure of Epinephrine.
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What are cholinergic receptors?
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Give the structure of pralidoxime chloride.
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What is Alprazolam?
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Give the structure and mechanism of action of Ethotoin.
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Give a brief note on inhalation anesthetics. Give one example.
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Give the structure of Levallorphan tartarate.
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Part B
Write a brief note on History and development of medicinal chemistry.
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What is meant by Hydrogen bonding? Explain with suitable examples.
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Give a brief account on optical isomers and explain how it is important in medicinal chemistry.
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Explain the principle involved in drug metabolism. Give few examples.
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Give the Biosynthesis of Catecholamine.
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Describe the mechanism of Metaraminol.
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Describe the mechanism of action and side effects of Prazosin.
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Give the SAR of beta blockers by taking Propranolol as example.
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Give the catabolism of acetylcholine.
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Give the SAR of parasympathomimetic agents.
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Describe the SAR of cholinolytic agents.
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Outline the synthetic route for the synthesis of Procyclidine hydrochloride.
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Explain the SAR of the benzodiazepines.
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What are Hydantoins? Give its synthesis.
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Give the structure and mechanism of Phenacemide.
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What is Glutethimide? Give its synthesis.
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Give the synthesis of Halothane.
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Describe the SAR of Morphine analogues.
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What is Nalorphine hydrochloride? Give its synthesis.
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Outline the synthesis of Ibuprofen.
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