JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy II Year MEDICINAL CHEMISTRY-I Previous Question Paper (September - 2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Define Chelation with examples.
Answer
Chelation is the formation of a stable, ring-like complex between a metal ion and a ligand (a molecule with two or more electron-donor groups). Examples include the complexation of tetracycline with calcium ions and the use of EDTA in treating heavy metal poisoning.
Discuss the role of partition coefficient in drug action.
Answer
The partition coefficient (P) measures a drug's lipophilicity, defined as the ratio of concentration in an organic phase (octanol) to an aqueous phase. It determines a drug's ability to cross biological membranes via passive diffusion; higher lipophilicity generally increases membrane permeability, while optimal balance is required for solubility and receptor binding.
What are adrenergic neurotransmitters?
Answer
Sign in to view the complete answer paper.
Write any two structures of beta adrenergic blockers.
Answer
Sign in to view the complete answer paper.
Write mechanism of action of carbachol.
Answer
Sign in to view the complete answer paper.
Give the structure and uses of Ipratropium bromide.
Answer
Sign in to view the complete answer paper.
Write the structure and use of Haloperidol.
Answer
Sign in to view the complete answer paper.
Give the structure and mechanism of action of Glutethimide.
Answer
Sign in to view the complete answer paper.
Classify general anesthetics with examples.
Answer
Sign in to view the complete answer paper.
Write the synthesis of Methadone hydrochloride.
Answer
Sign in to view the complete answer paper.
Part B
Write a brief note one History and development of medicinal chemistry.
Answer
Sign in to view the complete answer paper.
Give and brief account on optical isomers and explain how it is important in medicinal chemistry.
Answer
Sign in to view the complete answer paper.
What is meant by Hydrogen bonding? Explain with suitable examples.
Answer
Sign in to view the complete answer paper.
Explain any two Phase II metabolic reactions with examples.
Answer
Sign in to view the complete answer paper.
Explain in detail about SAR of Sympathomimetic agents.
Answer
Sign in to view the complete answer paper.
Write the synthesis and Mechanism of action of Tolazoline.
Answer
Sign in to view the complete answer paper.
Explain in detail about SAR of Beta blockers.
Answer
Sign in to view the complete answer paper.
Write the synthesis and Mechanism of action of Salbutamol.
Answer
Sign in to view the complete answer paper.
Describe the mechanism of action and side effects of Atropine and Physostigmine
Answer
Sign in to view the complete answer paper.
Classify cholinergic receptors and their bio distribution.
Answer
Sign in to view the complete answer paper.
Give the structures and uses of Pilocarpine and Dicyclomine hydrochloride.
Answer
Sign in to view the complete answer paper.
Explain the Biosynthesis of Acetylcholine.
Answer
Sign in to view the complete answer paper.
Explain SAR of Benzodiazepines and give the synthesis of Diazepam.
Answer
Sign in to view the complete answer paper.
Define Antipsychotics and classify them with suitable examples.
Answer
Sign in to view the complete answer paper.
Explain SAR of Phenothiazeines.
Answer
Sign in to view the complete answer paper.
Write the synthesis of Chlorpromazine hydrochloride.
Answer
Sign in to view the complete answer paper.
Write the mechanism of action of Methadone hydrochloride.
Answer
Sign in to view the complete answer paper.
Give the synthesis, mechanism of action, and uses of Mefenamic acid.
Answer
Sign in to view the complete answer paper.
Explain in detail about SAR of Morphine.
Answer
Sign in to view the complete answer paper.
Write the synthesis of Ketamine hydrochloride.
Answer
Sign in to view the complete answer paper.