Jawaharlal Nehru Technological University Hyderabad
Jawaharlal Nehru Technological University Hyderabad B.Pharmacy II PHYSICAL PHARMACEUTICS-II Previous Question Paper (April/May- 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Give units of basic rate constant in zero and second order reaction.
Answer
The units for the rate constant (k) are as follows:
- Zero order: mol L-1 s-1 (or concentration time-1).
- Second order: L mol-1 s-1 (or concentration-1 time-1).
In a first-order decomposition reaction, 50.0% of a compound decomposes in 20.00 min. What is the rate constant of the reaction?
Answer
For a first-order reaction, the rate constant is calculated using the half-life formula:
Given that 50% decomposition occurs in 20.00 min, the half-life (t1/2) is 20.00 min. Therefore:
What are Bulges and Spurs?
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Differentiate shear thinning and shear thickening systems of flow.
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Define suspension.
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Differentiate between creaming and cracking of emulsion.
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Write the difference between surface tension and interfacial tension.
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What are surface active agents and classify them with examples?
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Write the classification of colloids.
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State and explain Hardy Schulze rule.
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Part B
Elaborate the influence of temperature and solvent on the rate of decomposition of drugs.
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Explain how medicinal agents are stabilized against oxidation.
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Write the procedure for performing accelerated stability testing. How do you calculate the expiration date of dosage forms?
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Define viscosity and kinematic viscosity with formulas. Write the importance of viscosity in pharmacy.
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Write a note on Heckel equation.
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Explain the determination of viscosity by capillary method.
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Write about elastic deformation and thixotropy in formulation.
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Write the formulation of suspension. Add a note on interfacial properties of suspensions.
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Explain the rheological properties of emulsions.
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Phase equilibria
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Physical stability of emulsion
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Surface free energy
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Spreading coefficient.
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Write the mechanism of adsorption and explain various types of adsorption isotherms.
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Explain the concept of DLVO theory with energy curves. Write its application in stabilizing the colloidal dispersion.
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How does coacervation affects the colloids? Write the measures for their protection.
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Discuss in detail about optical and electrical properties of colloids.
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