JNTU
JNTU B.Pharmacy III Year MEDICINAL CHEMISTRY-III Previous Question Paper (February - 2023 - R17)
Note: i) Question paper consists of Part A, Part B.
ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions.
iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
PART A
What are β-lactam antibiotics? Mention any four of them.
Answer
β-lactam antibiotics are a class of antibacterial agents characterized by the presence of a four-membered β-lactam ring in their molecular structure, which inhibits bacterial cell wall synthesis. Four examples include: Penicillin G, Amoxicillin, Cephalexin, and Imipenem.
Write the structure of Streptomycin and Kanamycin.
Answer
Streptomycin is an aminoglycoside consisting of a streptidine ring linked to streptose and N-methyl-L-glucosamine. Kanamycin consists of a 2-deoxystreptamine ring substituted with two amino sugars, 6-amino-6-deoxy-D-glucose and 3-amino-3-deoxy-D-glucose.
Write the nomenclature and structure of Erythromycin.
Answer
Sign in to view the complete answer paper.
What are Prodrugs? Give few examples of them.
Answer
Sign in to view the complete answer paper.
Write the structure and uses of Ethionamide.
Answer
Sign in to view the complete answer paper.
Write the mechanism of action of Quinolones.
Answer
Sign in to view the complete answer paper.
Write a note on Synthetic Anti-fungal agents with few examples.
Answer
Sign in to view the complete answer paper.
Write the mechanism of action of folate reductase inhibitors with examples.
Answer
Sign in to view the complete answer paper.
Explain partition coefficient.
Answer
Sign in to view the complete answer paper.
Write about Pharmacophore modeling.
Answer
Sign in to view the complete answer paper.
PART B
Give the nomenclature, SAR and chemical degradation of Cephalosporins.
Answer
Sign in to view the complete answer paper.
Write the SAR of Tetracyclines. Write the therapeutic uses and adverse effects of Tetracyclines.
Answer
Sign in to view the complete answer paper.
Give the SAR of Macrolide Antibiotics. Write adverse effects and therapeutic uses of them.
Answer
Sign in to view the complete answer paper.
Write the etiology of Malaria. Give the synthesis of Pamaquine.
Answer
Sign in to view the complete answer paper.
Give the synthesis and nomenclature of Isoniazid. Write its adverse effects.
Answer
Sign in to view the complete answer paper.
Give the synthesis, adverse effects and uses of Acyclovir.
Answer
Sign in to view the complete answer paper.
Give the synthesis, adverse effects and uses of Miconazole.
Answer
Sign in to view the complete answer paper.
Write a note on the historical development, classification and chemistry of Sulfonamides. Write the synthesis of sulfacetamide.
Answer
Sign in to view the complete answer paper.
Explain the following Physico-chemical parameters used in QSAR:
Hammet’s electronic parameter
Answer
Sign in to view the complete answer paper.
Hansch Analysis.
Answer
Sign in to view the complete answer paper.
Explain in detail about the solid phase and solution phase synthesis.
Answer
Sign in to view the complete answer paper.