JNTU
JNTU B.Pharmacy III Year MEDICINAL CHEMISTRY-III Previous Question Paper (July - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
PART - A
What are Aminoglycosides Antibiotics?
Answer
Aminoglycosides are a class of broad-spectrum antibiotics characterized by amino sugars linked by glycosidic bonds to an aminocyclitol ring. They exert their bactericidal effect primarily by binding to the 30S ribosomal subunit, thereby inhibiting bacterial protein synthesis.
What are Tetracycline’s Antibiotics?
Answer
Tetracyclines are a group of broad-spectrum antibiotics defined by a common chemical structure consisting of four fused six-membered hydrocarbon rings. They act by reversibly binding to the 30S ribosomal subunit of susceptible bacteria, preventing the attachment of aminoacyl-tRNA to the mRNA-ribosome complex, thus inhibiting protein synthesis.
Write mechanism of action of Chloramphenicol.
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What are Macrolide antibiotics gives any two examples of macrolides.
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Outline the synthesis of Acyclovir.
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Write mechanism of action of Nitrofurantoin.
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Write the mechanism of action of antiprotozoal agents?
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Outline the synthesis of Diethylcarbamazine citrate.
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What do you mean by Combinatorial chemistry?
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What is docking?
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PART - B
Classify Beta-Lactamase inhibitors with their structure.
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Write SAR of cephalosporins.
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Discuss the chemical degradation of Penicillin.
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Write mechanism of action and use of Aminoglycoside drugs.
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Write down classification and applications of pro drugs.
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Write a short note on macrolides antibiotics.
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Write synthesis and use of Chloramphenicol.
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Write SAR of quinolone.
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Write SAR of quinolones as a Urinary tract anti-infective agents.
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Outline the synthesis and mechanism of action of isoniazid.
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Classify urinary tract anti-infective agents with example.
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What is Anti-viral agents? Write its classification with example.
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Write MOA and uses of sulfonamides.
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Explain Amphotericin-B as a Antifungal antibiotics.
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What are Anthelmintics agents? Classify them.
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Write synthesis and use of Tolnafate.
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Explain Hansch analysis.
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Explain the application of molecular docking.
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Explain Hammet’s electronic parameters in detail.
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Write application of solution phase combinatorial chemistry.
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