JNTU
JNTU B.Pharmacy III SCREENING METHODS IN PHARMACOLOGY Previous Question Paper (July - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Why is it important to follow regulations for laboratory animals in research?
Answer
Following regulations ensures ethical treatment, minimizes animal suffering, promotes scientific validity through standardized conditions, and maintains legal compliance with institutional and national animal welfare guidelines.
What are the key aspects of the care and handling of laboratory animals?
Answer
Key aspects include providing appropriate housing (temperature, humidity, ventilation), ensuring access to clean water and nutritionally balanced food, maintaining strict hygiene, implementing environmental enrichment, and using gentle handling techniques to minimize stress.
Mention the available OECD guideline for conducting acute toxicity studies.
Answer
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Define LD50 and its significance in toxicity studies.
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What are antidepressants and give any two examples.
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Mention the screening methods available for evaluating antiepileptic activity.
Answer
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Define hypertension.
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Write a note on congestive heart failure.
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Define analgesics.
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Mention the applications of Eddy’s hot plate.
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Part B
Explain the role and importance of CPSCEA guidelines in laboratory animal research.
Answer
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Describe one alternative method to animal studies that can be used in scientific research, highlighting its advantages and limitations.
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Compare and contrast acute, sub-acute, and chronic toxicity studies, including their duration, endpoints, and objectives.
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Describe the OECD guidelines for carrying out chronic toxicity studies.
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Discuss the specific considerations and parameters that are evaluated when assessing the pharmacological activity of antipsychotics.
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Describe the methods and techniques used in the screening process for evaluating antidepressants.
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Classify and briefly describe various screening methods commonly used to identify anti-diabetic activity.
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Describe various screening methods commonly used to identifying anti-ulcer and anti-hypertensive drug candidates.
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Classify and briefly describe various screening methods available for evaluating anti-inflammatory activity.
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Classify and briefly describe various screening methods available for evaluating anti-pyretic and analgesic activity.
Answer
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