JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B. Pharmacy IV MEDICINAL CHEMISTRY-II Previous Question Paper (December – 2023 / January -2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Write the general pharmacophore for Anti-histamines with one drug’s structure.
Answer
The general pharmacophore for H1-receptor antagonists consists of two aromatic rings (Ar1 and Ar2) linked to a central atom (C, N, or O), which is connected via a two-to-three carbon chain to a terminal tertiary amine group. Example: Diphenhydramine.
Write the name and mechanism of action of plant products as anticancer agents.
Answer
Prominent plant-derived anticancer agents include Vincristine and Vinblastine (Vinca alkaloids) and Paclitaxel (Taxanes). Their mechanism of action involves inhibiting mitosis by binding to tubulin, thereby preventing the assembly or disassembly of microtubules, which arrests the cell cycle in the metaphase stage.
Discuss about Potasium sparing diuretics
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Write the structure and mention the uses of Reserpine and Guabenz acetate.
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Write the structure and use of Lorcainide Hydrochloride.
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Write the clinical importance of Lovastatin. Explain its mechanism of action.
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Write the structure and use of Norgestril.
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Write the structure and uses of Diethyl stilbestrol.
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Give mechanism of action of Bigunides.
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Write the structure and uses of Acarbose.
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Part B
Write the structures of any two antihistamines with pyrimidine nucleus. Add a note on synthesis of Promethazine HCl.
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Write a note on Gastric proton pump inhibitors.
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Classify Anti-neoplastic agents with suitable examples. Explain the mechanism of action and therapeutic uses of antimetabolites.
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Write the synthesis Mechlorethamine and Diphenylhydramine.
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Write the synthesis and mechanism of action of any one Carbonic anhydrase inhibitors.
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Discuss the synthesis and mechanism of action of Furosemide.
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Write the classification of Anti-anginal. Explain the MOA of β-blocker and CCB classes of anti-anginal.
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Write a note on Vasodilators.
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Write a note on Classification of anti-arrhythmic drugs.
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Illustrate the classification of Cogulant and Anti-coagulants.
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Write a note on Antihyperlipidemic drugs.
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Write a note on drugs used in Congestive heart failure.
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Write a note on nomenclature of steroids.
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Write a note on srereochemistry of steroids.
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Discuss in detail of Mifepristone and Progesterone.
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Discuss biosynthesis of sex hormones and its roles.
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Detail on Insulin and its preparations.
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Write the synthesis, mechanism of action and uses of Tolbutamide.
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Write the synthesis and mechanism of action of Benzocaine
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Describe the local anesthetics activity of benzoic acid derivatives.
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