JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B. Pharmacy IV Year MEDICINAL CHEMISTRY - II Previous Question Paper (June/July - 2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, Answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
PART - A
Give the structure and uses of Diphenhydramine HCL.
Answer
The structure of Diphenhydramine hydrochloride is 2-(diphenylmethoxy)-N,N-dimethylethanamine hydrochloride. It consists of a benzhydryl ether group attached to an N,N-dimethylethylamine chain, forming a salt with hydrochloric acid.
Its primary uses include the treatment of allergic conditions such as rhinitis, urticaria, and pruritus. It is also used as an antiemetic for motion sickness, a mild sedative, and as an antitussive agent.
Give the mechanism of action of triprolidine hydrochloride.
Answer
Triprolidine hydrochloride acts as a potent, competitive, and reversible H1-receptor antagonist. It functions by binding to the H1-histamine receptors on effector cells, thereby preventing the binding of endogenous histamine to these receptors.
By blocking the H1 receptors, triprolidine inhibits the physiological effects typically mediated by histamine, such as capillary permeability, smooth muscle contraction in the bronchi and gastrointestinal tract, and the stimulation of sensory nerve endings that lead to itching and sneezing. Because it is an inverse agonist, it also suppresses the constitutive activity of the H1 receptor, effectively reducing allergic symptoms associated with conditions like rhinitis and urticaria.
Give the structure and nomenclature of furosemide.
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What is angina pectoris? Give the uses of nitroglycerin.
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Outline the structure and nomenclature of warfarin.
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Enlist the drugs used in congestive heart failure and write down mechanism of action of digitoxin.
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Give the structure and uses of prednisolone.
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Define thyroid and antithyroid drug with example.
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Enlist the lidocaine/anilide derivatives drugs with structure.
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Give the mechanism and uses of Benzocaine.
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PART - B
Explain SAR of H1 Receptor antagonist drugs.
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Give the classification of alkylating agent with example and synthesis of Meclorethamine.
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Define antimetabolites? Write the synthesis and uses of Mercaptopurine.
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What is antibiotics. Give the mechanism of action and uses of bleomycin.
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Write a short note on carbonic anhydrase inhibitors.
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Write a short note on potassium sparing diuretics.
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Define antihypertensive Drugs and give synthesis and mechanism of action of Methyldopate hydrochloride.
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Give the general mechanism of action and outline the synthesis of Chlorthiazide.
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Write a note on coagulant and anti-coagulant drugs.
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Write classify of Antiarrhythmic drugs structure of each drug belong to each class.
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Give its mechanism of action and outline the synthesis of Disopyramide phosphate.
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Explain the mechanism of action and use of clofibrate and lovastatin.
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Explain the female sex hormone.
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Enlist the drug use in oral contraceptive and give the mechanism of action of levonogrestrol.
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Explain the mechanism of action and use of sildenafil and tadalafil.
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Explain metabolism of steroids.
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Define Anesthetic drugs and Give the SAR of Local Anesthetic drugs.
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Write a short note on benzoic acid derivatives.
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Give the classification of anti-diabetic drugs, explain the mechanism of action of glucosidase inhibitors.
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Enlist the drugs of sulphonyl ureas and outline the synthesis of tolbutamide.
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