JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy IV NOVEL DRUG DELIVERY SYSTEMS Previous Question Paper (June / July - 2024 - R17)
i) Question paper consists of Part A, Part B.
ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions.
iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
PART - A
Define sustained and controlled release drug delivery system.
Answer
Sustained release refers to a drug delivery system that provides a slow, continuous release of a drug over a prolonged period, maintaining therapeutic blood levels. Controlled release systems provide a predictable, predetermined, and reproducible release rate of the drug, often independent of the gastrointestinal environment.
Explain the considerations for the selection of polymers.
Answer
The selection of polymers depends on: 1) Biocompatibility and Toxicity: The polymer must be non-toxic, non-irritating, and inert. 2) Physicochemical Properties: Factors like molecular weight, solubility, crystallinity, and glass transition temperature influence drug release kinetics. 3) Degradability: For biodegradable systems, the rate of polymer degradation must match the desired drug release profile.
What is OROS-CT osmotic system?
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Enlist the factors affecting transdermal permeability.
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Enlist two advantages of GRDDS.
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What are floating systems?
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How nanoparticles are used as target drug delivery system?
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List the advantages of Liposomes.
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State the advantages of Ocuserts.
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What are contraceptive patches?
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PART - B
What are the factors affecting formulations of oral sustain release drug delivery system? State and discuss in details.
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What is natural polymer? Give its merits and demerits. Explain its physical and chemical properties.
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Write a note on biodegradable synthetic polymers.
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Discuss in detail different methods of microencapsulations.
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What do you mean by implantable drug delivery systems? Explain the methods of implant preparation.
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Explain about microballons as GRDDS.
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What are permeation enhancers? Discuss the basic components of TDDS formulations.
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Write a note on pulmonary route as a promising route of drug administration.
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Critically discuss the factors to be considered to overcome the pharmacokinetic challenges of nasopulmonary drug delivery system.
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Distinguish phytosomes and neosomes. Explain their method of preparations.
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Discuss about the toxicity of nanoparticles.
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Explain the concept, advantages, disadvantages of nanoparticles.
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Discuss the methods of characterization of nanoformulations.
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Give a brief account of osomotically regulated ocuserts.
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Briefly discuss intravaginal drug delivery system.
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What are intrauterine drug delivery systems? Write their applications.
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Write a note on intraocular barriers and methods to overcome them.
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