JNTU
JNTU B.Pharmacy IV EXPERIMENTAL PHARMACOLOGY Previous Question Paper (August/September - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
PART A
What are transgenic animals?
Answer
Transgenic animals are organisms whose genetic material has been altered by the introduction of foreign DNA sequences (transgenes) into their genome using recombinant DNA technology. These animals are used in research to study gene function, model human diseases, and test therapeutic interventions.
Write about Euthanasia.
Answer
Euthanasia is the act of inducing humane death in laboratory animals with minimal pain, distress, or anxiety. It must be performed by trained personnel using approved methods, such as barbiturate overdose, inhalation of anesthetic gases, or carbon dioxide asphyxiation, ensuring the animal is unconscious before death occurs, in accordance with CPCSEA guidelines.
How the dose calculation for animals are done as per FDA guidelines.
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How many animal grouping are done for preclinical studies.
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Name 4 skeletal muscle relaxants.
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Write the preclinical screening models for analgesic activity.
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Enlist the anticancer activity model.
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What is carbonic anhydrate inhibitory test? How it is prepared.
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List out bio-statistics methods.
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What is meant by one way ANOVA?
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PART B
Describe the various routes of drug administration in laboratory animals and mention their advantages and disadvantages.
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Alternatives to animal experiments.
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Common laboratory animals for experimentation.
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List four drugs used to anaesthetize lab animals.
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Write the importance of sham negative and positive control groups.
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How the dose selected for preclinical studies? Write the different preclinical models for anti inflammatory testing.
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Describe experimental models available to screen a potential immunosuppressant agent.
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Write the principle involved in study of cholinergic and anticholinergics drug by mydriatic effects in rabbits.
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Write invitro-invivo models for diuretics preclinical studies.
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Write invitro-invivo models for anti coagulants preclinical studies.
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Describe current concepts in use of animals in drug research with special reference to ethics.
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Selection of research topic
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ANOVA.
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