JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy I Year BIOCHEMISTRY Previous Question Paper (June/July - 2018 - R17)
Note: This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b, c as sub questions.
PART-A
What is diabetes Mellitus.
Answer
Diabetes Mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both, leading to disturbances in carbohydrate, fat, and protein metabolism.
Write briefly about Oxidative phosphorylation & its mechanism.
Answer
Oxidative phosphorylation is the process in mitochondria where ATP is synthesized from ADP and inorganic phosphate using energy released from electron transport. The mechanism involves the chemiosmotic hypothesis, where electron transfer through the respiratory chain complexes pumps protons into the intermembrane space, creating an electrochemical gradient that drives ATP synthase to produce ATP.
Write a note on essential amino acids.
Answer
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Discuss about metabolic disorders of aromatic aminoacids.
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Write note on Hyperuricemia and Gout disease.
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Write about structure of DNA.
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Describe briefly about biological role of lipids.
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Write a note on Energy rich Compounds.
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Write in brief on lyases.
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Write therapeutic and diagnostic applications of enzymes.
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PART-B
What is Glycolysis? Write its pathway?
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Describe Oxidative phosphorylation.
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Write the significance of HMP shunt pathway?
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Explain the metabolism of glycogen in detail?
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Write a note on Ketogenesis.
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Write the importance of Urea cycle and discuss the metabolic disorders of urea cycle.
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Describe the bio synthesis of fatty acids.
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Write the reactions involved in the metabolism of phenylalanine.
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Discuss the structural aspects of DNA and tRNA.
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Describe catabolism of purine nucleotides.
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Describe the metabolic pathway for the synthesis of Pyrimidine nucleotide.
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Discuss DNA replication and transcription in protein synthesis.
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Write the relationship between free energy, enthalpy and entropy.
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Write short notes on Redox potential.
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Write the classification and biological significance of ATP and cyclic AMP.
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Write the classification of Biomolecules. Explain the biological role of Biomolecules.
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What are enzymes? Write the nomenclature of enzymes.
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Discuss enzyme kinetics in detail.
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Write a note on reversible and irreversible enzyme inhibitors.
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Discuss the significance of enzyme inhibitors in health and disease.
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