JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy I BIOCHEMISTRY Previous Question Paper (March - 2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
List the inhibitors involved in electron transport chain.
Answer
Inhibitors of the electron transport chain (ETC) act by blocking specific complexes or the ATP synthase enzyme. The primary inhibitors include:
- Complex I (NADH dehydrogenase) inhibitors: Rotenone, Amytal, and Piericidin A.
- Complex III (Cytochrome bc1 complex) inhibitors: Antimycin A and Dimercaprol.
- Complex IV (Cytochrome c oxidase) inhibitors: Cyanide, Carbon monoxide, and Azide.
- ATP synthase inhibitor: Oligomycin.
Sketch the flowchart of Glycogenesis pathway.
Answer
Glycogenesis is the process of glycogen synthesis from glucose. The pathway involves the following sequence of reactions:
- Glucose is phosphorylated to Glucose-6-phosphate by hexokinase or glucokinase.
- Glucose-6-phosphate is converted to Glucose-1-phosphate by phosphoglucomutase.
- Glucose-1-phosphate reacts with UTP to form UDP-glucose, catalyzed by UDP-glucose pyrophosphorylase.
- Glycogen synthase adds glucose units from UDP-glucose to a pre-existing glycogen primer (glycogenin).
- Branching enzyme (amylo-(1,4→1,6)-transglycosylase) creates α-1,6-glycosidic linkages to form the branched structure of glycogen.
Mention the biological significance of dopamine.
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Briefly describe about Transamination.
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Write the basic structure of purine and pyrimidine ring.
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Briefly tell about reverse transcription.
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What is the biological significance of ATP?
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Give the classification of high energy compounds.
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What is holoenzyme and give one example of holoenzyme.
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Describe about the six classes of enzymes.
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Part B
Explain about the citric acid cycle.
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What happens due to Glucose-6-Phosphate dehydrogenase (G6PD) deficiency.
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Explain in detail about the electron transport chain and its mechanism.
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Add a brief note on uncouplers involved in oxidative phosphorylation.
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Add a detailed note on α-oxidation of saturated fatty acid.
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Describe the synthesis and significance of melatonin.
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Describe how the cholesterol is converted into bile acids, steroid hormone and vitamin D.
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Describe briefly about catabolism of heme.
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Describe in detail about the biosynthesis of purine ribonucleotide.
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Describe about hyperuricemia and gout disease.
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Explain about the transcription process.
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Add a brief note on inhibitors of protein synthesis.
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Elaborate on the relationship between free energy, enthalpy and entropy.
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Write the classification and biological role of carbohydrates.
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Explain in detail about exergonic and endergonic reactions.
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Mention the chemical nature and biological role of proteins.
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Explain in detail about enzyme kinetics by Michaelis plot.
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Describe in detail about allosteric enzymes regulation.
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Write in detail about enzyme inhibitors with examples.
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Mention the diagnostic applications of enzymes, isoenzymes and Coenzymes.
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