JNTU
JNTU B. Pharmacy II Year PHYSICAL PHARMACEUTICS-I Previous Question Paper (May/June- 2019 - R17)
Note: This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b, c as sub questions.
PART-A
Define Molar Refraction.
Answer
Molar refraction is defined as the product of the molar volume and the Lorentz-Lorenz function of the refractive index. It is a molar property that is independent of temperature and pressure, providing a measure of the total polarizability of a mole of a substance.
Explain the terms amorphous and polymorphism.
Answer
Amorphous substances are solids that lack a long-range ordered crystalline structure, often appearing as disordered or glass-like materials with no defined melting point. Polymorphism is the ability of a solid material to exist in more than one crystalline form or structure, which can significantly influence the physical and chemical properties of a drug, such as solubility and stability.
What is fractional distillation?
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Write the applications of Critical Solution Temperature.
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Define equivalent spherical diameter.
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Write various methods to determine particle size and surface area.
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Define protein binding.
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Write the applications of complexes.
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Define pH.
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Write the applications of buffers.
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PART-B
What are the properties of gases? Derive an equation for an ideal gas.
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Explain in detail the properties and significance of liquid crystals.
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Write short notes on Aerosols-Inhalers.
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Explain about refractive index and optical rotation.
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Explain about azeotropic mixtures.
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Write short notes on dissolution and drug release.
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Explain solubility of gas in liquids.
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Write short notes on distribution law, its limitations and applications.
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Define specific surface area and elaborate on determination of surface area by adsorption method.
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Write a note on particle dimensions in pharmaceutical dispersion system.
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Explain in detail the determination of particle size by microscopy and sieving method.
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Explain flow properties of powders and packing arrangement of powders.
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Write short notes on inclusion compounds.
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Explain organic molecular complexes with examples.
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What is the significance of complexation on drug action.
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Write the method of analysis of complexes by pH titration method.
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Derive buffer equation for a weak acid.
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Describe in detail the methods of adjusting tonicity by Cryoscopic and Sodium Chloride Equivalent method.
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Write short notes on buffers in pharmaceutical and biological systems.
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Explain buffered isotonic solutions.
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