JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B.Pharmacy II Year PHARMACOLOGY - I Previous Question Paper (March - 2024 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
Define agonist.
Answer
An agonist is a drug or endogenous substance that binds to a specific receptor and activates it to produce a biological response, possessing both affinity for the receptor and intrinsic activity.
What is drug tolerance?
Answer
Drug tolerance is a state of decreased responsiveness to the pharmacological effects of a drug resulting from its repeated administration. It necessitates an increase in the dose to achieve the same therapeutic effect originally produced by a lower dose.
Define therapeutic index.
Answer
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Outline two example of drug interactions due to alterations in metabolism.
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Define denervation supersensitivity.
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Outline beta receptors with their location and characteristics.
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Name receptors of dopamine.
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What is synaptic plasticity?
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Define drug addiction.
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What are nootropic agents?
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Part B
Discuss factors affecting distribution of drugs.
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Explain effect of pH and ionization on drug absorption.
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Elaborate role of cytochrome P450 in drug metabolism.
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List parenteral routes of drug administration. Discuss its advantages and disadvantages.
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With the help of neat labelled diagram, explain the structure of type II receptors.
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Discuss phase I clinical trials in detail.
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Discuss signal transduction mechanism of kinase linked receptors.
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Elaborate the importance of pharmacovigilance.
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What is Dale’s vasomotor reversal?
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Classify parasympathomimetics with examples.
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Write a note on local anaesthetics.
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Compare and contrast depolarizing and non-depolarizing neuromuscular blockers.
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Justify use of disulfiram for alcohol abuse.
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Give a brief account of pre-anesthetic medications.
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Discuss mechanism of action and side effects of anti-epileptics acting through calcium channel.
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Explain pharmacological actions and therapeutic uses of benzodiazepines.
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Discuss mechanism of action and pharmacological actions of SSRIs.
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Justify the use of carbidopa with levodopa.
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Classify drugs used in Alzheimer’s Disease with examples.
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Discuss pharmacology of opioid antagonists.
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