Jawaharlal Nehru Technological University Hyderabad
Jawaharlal Nehru Technological University Hyderabad B.Pharmacy II PHARMACOLOGY-I Previous Question Paper (September/October - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
What is cytochrome p450 enzyme inhibition?
Answer
Cytochrome P450 (CYP450) enzyme inhibition refers to the decrease in the catalytic activity of these hepatic microsomal enzymes by a drug, leading to reduced metabolism of other co-administered drugs. This interaction often results in increased plasma concentrations, prolonged duration of action, and potential toxicity of the substrate drug.
Outline tolerance and dependence.
Answer
Tolerance is a state of reduced responsiveness to a drug following repeated administration, requiring higher doses to achieve the same pharmacological effect. Dependence is an adaptive state characterized by physical or psychological disturbances upon the abrupt cessation of a drug, often manifesting as withdrawal symptoms.
Give two examples of type 3 receptors.
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What is the importance of pharmacovigilance?
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What is denervation supersensitivity?
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Comment: Propranolol should not be used in diabetic patients.
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Summarize glutamate as excitatory neurotransmitter.
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What is flumazenil? Give its use.
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What are nootropic agents?
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Justify use of selegilline in combination with levodopa.
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Part B
Explain methods to enhance drug absorption.
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Describe factors affecting drug distribution.
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Describe advantages and disadvantages of oral route of drug administration.
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Explain excretion of drugs via non-renal route.
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Differentiate between Type A and Type B Adverse Drug Reactions.
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Describe drug interactions occurring due to alterations in absorption of drugs.
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Explain functions of G-proteins in type 2 receptors.
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Describe phase III clinical trials.
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Classify local anesthetics with examples.
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Describe pharmacological actions and side effects of parasympatholytics.
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Explain Dale’s vasomotor reversal.
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Compare and contrast depolarizing and non-depolarizing agents.
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Give mechanism of action of anti-epileptics acting through sodium channels.
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Give classification of general anesthetics.
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Justify use of disulfiram in alcohol de-addiction.
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Describe mechanism of action and pharmacology of barbiturates.
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Describe disadvantages of typical anti-psychotic agents.
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Explain mechanism of action and side effects of SSRIs.
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Elaborate the pharmacological actions and side effects of anti-cholinesterases used in Alzheimer’s Disease.
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Give a detailed account of opioid antagonists.
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