JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD B. Pharmacy II PHARMACEUTICAL ORGANIC CHEMISTRY – III Previous Question Paper (April/May - 2023 - R17)
Note: i) Question paper consists of Part A, Part B. ii) Part A is compulsory, which carries 25 marks. In Part A, answer all questions. iii) In Part B, Answer any one question from each unit. Each question carries 10 marks and may have a, b as sub questions.
Part A
What is resolution of racemic mixture.
Answer
Resolution is the process of separating a racemic mixture (an equimolar mixture of two enantiomers) into its individual pure enantiomeric components.
Define chiral and achiral molecules. Give examples.
Answer
A chiral molecule is one that is non-superimposable on its mirror image, typically due to the presence of a chiral center (e.g., lactic acid). An achiral molecule is superimposable on its mirror image, often possessing a plane or center of symmetry (e.g., glycine or propane).
What are geometrical isomers?
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Mention the conditions required for the optical activity.
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Mention the medicinal uses of furan containing compounds.
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Thiophen is aromatic. Explain how?
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Write the medicinal importance of pyridine and pyrimidine.
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Outline the chemical synthesis of acridine.
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List the applications of Claisen-Schmidt condensation.
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Outline about Birch reduction.
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Part B
Differentiate enantiomers from diastereomers.
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Explain about Cahn-Ingold-Prelog rules for assigning RS configurations.
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Explain about optical isomerism.
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Describe elements of symmetry.
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Give a note on nomenclature of geometrical isomers.
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Write about stereo isomerism in biphenyl compounds.
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Explain the methods of determination of configuration of geometrical isomers.
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Explain the conformational isomerism of n-Butane.
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Describe the reactivity and orientation of electrophilic substitution reactions of pyrrole.
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Write one general method of preparation each for furan and pyrrole.
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Outline the synthesis methods and reactivity of thiophen.
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Define and classify heterocyclic compounds.
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Give a note on synthesis, reactions and medicinal uses of imidazole.
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Electrophilic substitution in pyrazole occurs at 4th position. Explain.
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Discuss the synthesis and reactions of indole.
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Explain the synthesis and medicinal uses pyrimidine and azepine.
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Define and explain the reaction mechanism of: i) Dakin reaction ii) Claisen-Schmidt condensation
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Give a note on pharmaceutical applications of Oppenauer-oxidation.
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Define reduction and rearrangement reactions.
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Describe the reaction mechanism and pharmaceutical applications of: i) Beckmann’s rearrangement ii) Schmidt rearrangement.
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