Jawaharlal Nehru Technological University Hyderabad
Jawaharlal Nehru Technological University Hyderabad B.Pharmacy II PHARMACEUTICAL ORGANIC CHEMISTRY-III Previous Question Paper (May-2019 - R17)
Note: This question paper contains two parts A and B. Part A is compulsory which carries 25 marks. Answer all questions in Part A. Part B consists of 5 Units. Answer any one full question from each unit. Each question carries 10 marks and may have a, b, c as sub questions.
PART- A
What is meant by enantiomerism? Give the examples of enantiomers.
Answer
Enantiomerism is a form of stereoisomerism where two molecules are non-superimposable mirror images of each other. These isomers are known as enantiomers. Examples include D-lactic acid and L-lactic acid, or the R and S configurations of glyceraldehyde.
Describe in detail about the Elements of symmetry. Give the suitable example for each.
Answer
Elements of symmetry are geometric features that determine the chirality of a molecule:
- Plane of symmetry (σ): An imaginary plane that divides a molecule into two mirror-image halves. Example: Meso-tartaric acid.
- Center of symmetry (i): A point in the molecule such that any line drawn through it meets equivalent atoms at equal distances. Example: Trans-1,3-dichloro-cyclobutane.
- Axis of symmetry (Cn): An imaginary line about which rotation by 360/n degrees results in an identical orientation. Example: Water molecule (C2 axis).
Explain the Conformational isomerism in Ethane.
Answer
Sign in to view the complete answer paper.
Describe in brief about the Geometrical isomerism.
Answer
Sign in to view the complete answer paper.
Give the classification of heterocyclic compounds.
Answer
Sign in to view the complete answer paper.
Give the various methods for the synthesis of thiophenes.
Answer
Sign in to view the complete answer paper.
Describe in detail the reactions of Thiazoles.
Answer
Sign in to view the complete answer paper.
Describe in detail the medicinal uses of Purine.
Answer
Sign in to view the complete answer paper.
Explain in detail about the Oppenauer-oxidation.
Answer
Sign in to view the complete answer paper.
What is LiAlH4? Give the mechanism of LiAlH4 reduction reaction.
Answer
Sign in to view the complete answer paper.
PART-B
Give in detail about the RS system of nomenclature of optical isomers and describe the sequence rules.
Answer
Sign in to view the complete answer paper.
Explain in detail about the chirality with suitable example.
Answer
Sign in to view the complete answer paper.
What is meant by Racemic modification. Give its importance in stereochemistry.
Answer
Sign in to view the complete answer paper.
Explain with suitable examples about the resolution of racemic mixtures.
Answer
Sign in to view the complete answer paper.
Give the Conformational isomerism in Cyclohexane.
Answer
Sign in to view the complete answer paper.
Describe the conditions for optical activity in biphenyl compounds.
Answer
Sign in to view the complete answer paper.
Give the example of Syn Anti systems of geometrical isomerism.
Answer
Sign in to view the complete answer paper.
Describe the chemical method for the Determination of configuration of cis-trans Isomers.
Answer
Sign in to view the complete answer paper.
Describe the Synthesis, reactions and medicinal uses of Furan.
Answer
Sign in to view the complete answer paper.
Give the reactivity of Thiophene compounds.
Answer
Sign in to view the complete answer paper.
Give the medicinal uses of furan.
Answer
Sign in to view the complete answer paper.
Give the nomenclature of pyrrole.
Answer
Sign in to view the complete answer paper.
Give the various methods of the Synthesis oxazoles.
Answer
Sign in to view the complete answer paper.
Give the three methods for the synthesis of isoquinolines.
Answer
Sign in to view the complete answer paper.
Describe the Basicity of pyridines.
Answer
Sign in to view the complete answer paper.
Give reactions and medicinal uses of Imidazole.
Answer
Sign in to view the complete answer paper.
What is Dakin reaction. Give its mechanism and give three applications.
Answer
Sign in to view the complete answer paper.
Give an account of Wolff Kishner reduction.
Answer
Sign in to view the complete answer paper.
Give the application of Claisen-Schmidt condensation.
Answer
Sign in to view the complete answer paper.
Give the application of NaBH4 reduction reaction.
Answer
Sign in to view the complete answer paper.